FDA Drug Recalls

Recalls / Class II

Class IID-0116-2025

Product

Hylenex recombinant (hyaluronidase) injection, 150 USP units/mL, 4x1 mL Single Dose Vials, Rx only, Manufactured for and marketed by Halozyme, Inc., 12390 El Camino Real San Diego California 92130, Distributed by Antares Pharma, Inc., Ewing, NJ NDC 18657-117-04

Brand name
Hylenex Recombinant
Generic name
Hyaluronidase
Active ingredient
Hyaluronidase (human Recombinant)
Route
Subcutaneous
NDC
18657-117
FDA application
BLA021859
Affected lot / code info
Serial # 100000831961 100000820688 100000820689 100000820515

Why it was recalled

cGMP Deviations: Temperature excursion

Recalling firm

Firm
Mckesson Medical-Surgical Inc. Corporate Office
Manufacturer
Antares Pharma, Inc.
Notification channel
Letter
Type
Voluntary: Firm initiated
Address
9954 Maryland Drive, Deep Run Iii Ste. 4000, Richmond, Virginia 23233

Distribution

Quantity
5 cartons/20 units each carton
Distribution pattern
Virgina

Timeline

Recall initiated
2024-09-11
FDA classified
2024-12-10
Posted by FDA
2024-12-18
Terminated
2025-08-20
Status
Terminated

Source: openFDA Drug Enforcement endpoint. Recall record D-0116-2025. The FDA issues recall classifications as health-hazard assessments, not legal findings; for legal claims consult a licensed attorney.

Class II recall: Hylenex Recombinant · FDA Drug Recalls