FDA Drug Recalls

Recalls / Class II

Class IID-1681-2012

Product

Methotrexate Injection, USP, 25 mg/mL, 40 mL Single Dose Vial, Rx only, antineoplastic/cytotoxic agent; Manufactured for Hospira, Inc., Lake Forest, IL 60045, Product of Australia; NDC 61703-408-41

Brand name
Methotrexate
Generic name
Methotrexate
Active ingredient
Methotrexate Sodium
Route
Intramuscular, Intravenous, Subcutaneous
NDCs
61703-350, 61703-408
FDA application
NDA011719
Affected lot / code info
lot number Y064457AA, exp OCT 2013 Rest of world lot numbers: list M4457A001, lot number Y054457AB, exp SEP 2013

Why it was recalled

The affected lots of Carboplatin Injection, Cytarabine Injection, Methotrexate Injection, USP, and Paclitaxel Injection are being recalled due to visible particles embedded in the glass located at the neck of the vial. There may be the potential for product to come into contact with the embedded particles and the particles may become dislodged into the solution.

Recalling firm

Firm
Hospira Inc.
Manufacturer
Hospira, Inc.
Notification channel
Letter
Type
Voluntary: Firm initiated
Address
275 N Field Dr, Lake Forest, Illinois 60045-2579

Distribution

Quantity
34,572 vials
Distribution pattern
Nationwide, including Puerto Rico and Guam. Product was also distributed internationally to Australia, Belgium, Canada, France, Germany, Korea, Malaysia, New Zealand, Norway, Pakistan, Philippines, Portugal, Singapore, Sweden, Thailand and Vietnam

Timeline

Recall initiated
2012-06-27
FDA classified
2012-09-19
Posted by FDA
2012-09-26
Terminated
2016-12-15
Status
Terminated

Source: openFDA Drug Enforcement endpoint. Recall record D-1681-2012. The FDA issues recall classifications as health-hazard assessments, not legal findings; for legal claims consult a licensed attorney.